IgG4-related disease involving the sclera

Mod Rheumatol. 2014 Jan;24(1):195-8. doi: 10.3109/14397595.2013.852842.


A 49-year-old female patient previously treated for scleritis and uveitis-induced cataract in the right eye presented with a subretinal white lesion in the same eye. With a preliminary diagnosis of choroidal tumor, enucleation of the eyeball was performed in accordance with the patient's request. Histologic and immunohistologic examinations were consistent with immunoglobulin G4-related disease. The case demonstrates that it is important to consider IgG4-related disease in the differential diagnosis of an intraocular tumor.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Autoimmune Diseases / diagnosis*
  • Autoimmune Diseases / immunology
  • Autoimmune Diseases / pathology
  • Diagnosis, Differential
  • Eye Neoplasms / diagnosis*
  • Eye Neoplasms / immunology
  • Eye Neoplasms / pathology
  • Female
  • Humans
  • Immunoglobulin G / immunology*
  • Middle Aged
  • Sclera / pathology*
  • Scleritis / diagnosis*
  • Scleritis / immunology
  • Scleritis / pathology


  • Immunoglobulin G