Influenza nucleoprotein-specific cytotoxic T-cell clones are protective in vivo

Immunology. 1986 Jul;58(3):417-20.


Influenza nucleoprotein (NP) serves as a target antigen on abortively infected cells for cytotoxic T cells (Tc) cross-reactive for all type A influenza viruses, and it can also prime mice for such Tc. It is important to test the protective ability of NP-specific Tc clones in vivo in a productive influenza infection. In this report, we show that Tc clones of this antigenic specificity protect mice against a lethal influenza infection on transfer to syngeneic recipients, and also that they reduce virus titres in the lungs and trachea of mice challenged with homologous or heterologous type A influenza viruses. Simultaneous injection of IL-2 to maintain the viability of the Tc clones is not essential, but has made the clonal transfer experiments highly reproducible.

MeSH terms

  • Animals
  • Antigens, Viral / immunology*
  • Clone Cells / immunology
  • Epitopes / immunology*
  • Influenza A virus / growth & development
  • Influenza A virus / immunology*
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Orthomyxoviridae Infections / immunology*
  • T-Lymphocytes, Cytotoxic / immunology*


  • Antigens, Viral
  • Epitopes