Advances in immunopathogenesis of adult immune thrombocytopenia

Front Med. 2013 Dec;7(4):418-24. doi: 10.1007/s11684-013-0297-8. Epub 2013 Nov 21.

Abstract

Primary immune thrombocytopenia (ITP) is an autoimmune disorder characterized by immune-mediated accelerated platelet destruction and/or suppressed platelet production. Although the development of autoantibodies against platelet glycoproteins remains central in the pathophysiology of ITP, several abnormalities involving the cellular mechanisms of immune modulation have been identified, and the pathways behind the immune-mediated destruction of platelets have opened new avenues for the design of specific immunotherapies in an attempt to reduce the platelet destruction. This review is primarily focused on the recent literature with respect to immunopathological mechanisms in patients with ITP.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adult
  • Autoantibodies / immunology
  • B-Lymphocytes / immunology
  • Blood Platelets / immunology
  • Humans
  • Macrophages / immunology
  • Purpura, Thrombocytopenic, Idiopathic / immunology*
  • T-Lymphocytes / immunology

Substances

  • Autoantibodies