Low-level lead exposure and the time-dependent organ-tissue distribution of essential elements in the neonatal rat

G D Miller; T F Massaro; E Koperek; E J Massaro

doi:10.1007/BF02987205

Low-level lead exposure and the time-dependent organ-tissue distribution of essential elements in the neonatal rat

Biol Trace Elem Res. 1984 Dec;6(6):519-30. doi: 10.1007/BF02987205.

Authors

G D Miller¹, T F Massaro, E Koperek, E J Massaro

Affiliation

¹ Nutrition Program, College of Human Development, The Pennsylvania State University, University Park, 16801, Pennsylvania.

PMID: 24264308
DOI: 10.1007/BF02987205

Abstract

Effects of low level lead (Pb) exposure on the time-dependent organ-tissue distribution of zinc (Zn), iron (Fe), copper (Cu), and calcium (Ca) were investigated in the neonatal rat. Pups were exposed to Pb acetate (50 mg/kg) via intragastric intubation at 3-d intervals from day 6 postpartum to day 18. This level of Pb exposure had no significant effect on body weight. Exposure to Pb resulted in an alteration of the normal, time-dependent organ distribution of the essential elements and significantly lower concentrations of Zn were found in brain, liver, kidney, and femur of Pb-treated animals.