Committee Opinion No.580: von Willebrand disease in women

Obstet Gynecol. 2013 Dec;122(6):1368-73. doi: 10.1097/01.AOG.0000438961.38979.19.


Von Willebrand disease, the most common inherited bleeding disorder among American women, is a common cause of heavy menstrual bleeding and other bleeding problems in women and adolescent girls. Von Willebrand disease and other inherited and acquired disorders of coagulation and hemostasis should be considered in the differential diagnosis of all patients being evaluated for heavy menstrual bleeding, regardless of age. There are many treatment options available for patients with von Willebrand disease and heavy menstrual bleeding, including hormonal and nonhormonal therapies. A multidisciplinary approach to management, which involves obstetrician-gynecologists and hematologists, results in optimal treatment outcomes. Many resources exist for patients and health care providers through the National Heart, Lung, and Blood Institute; National Hemophilia Foundation; and the American Society of Hematology.

MeSH terms

  • Antifibrinolytic Agents / therapeutic use
  • Female
  • Hormones / therapeutic use
  • Humans
  • Menorrhagia / drug therapy
  • Menorrhagia / etiology*
  • Pregnancy
  • Pregnancy Complications, Hematologic / blood*
  • von Willebrand Diseases / blood
  • von Willebrand Diseases / complications*
  • von Willebrand Diseases / diagnosis*
  • von Willebrand Diseases / drug therapy
  • von Willebrand Factor / metabolism


  • Antifibrinolytic Agents
  • Hormones
  • von Willebrand Factor