Bleomycin-induced nodular pulmonary fibrosis masquerading as metastatic testicular cancer

J Urol. 1986 Aug;136(2):473-5. doi: 10.1016/s0022-5347(17)44914-7.

Abstract

Bleomycin has become an important component of combination chemotherapy, particularly in the treatment of metastatic testis carcinoma. Pulmonary toxicity is a major risk and irreversible pulmonary fibrosis or even death may result from its use. Rarely diffuse fibrosis may lead to discrete nodularity mimicking pulmonary metastasis. We report such a case, and discuss the various clinical, radiographic and histopathological forms of bleomycin-induced pulmonary toxicity.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Bleomycin / administration & dosage
  • Bleomycin / adverse effects*
  • Combined Modality Therapy
  • Diagnosis, Differential
  • Humans
  • Lung Neoplasms / secondary*
  • Male
  • Pulmonary Fibrosis / chemically induced*
  • Pulmonary Fibrosis / diagnosis
  • Teratoma / secondary*
  • Teratoma / therapy
  • Testicular Neoplasms / pathology*
  • Testicular Neoplasms / therapy

Substances

  • Bleomycin