Study of the genetic determination of the gliadins of two F2 progenies from bread wheat has enabled (1) confirmation of the co-dominant heredity of the presence of these bands in the F1, and (2) determination of the transmission of the presence/absence character for 20 bands. 10 bands are monogenically controlled; 10 others are coded by two pairs of alleles. Among the latter 2 bands split into two proteins in 2 dimensional electrophoresis. Analysis of the segregations, not taking into consideration the presence/absence character but only the concentrations of certain bands, led to the formulation of the hypothesis of regulator genes controlling the expression of structural genes.