Anticonvulsant and neuroprotective effects of oligosaccharides from Lingzhi or Reishi medicinal mushroom, Ganoderma lucidum (Higher Basidiomycetes)

Int J Med Mushrooms. 2013;15(6):555-68. doi: 10.1615/intjmedmushr.v15.i6.40.

Abstract

An oligosaccharide fraction isolated from the mycelium of the Lingzhi or Reishi medicinal mushroom Ganoderma lucidum (GLOS) was separated by size-exclusion chromatography. The chemical structure of GLOS consists of a disaccharide repeating unit [-4-β-1-Galf(1-6)-O-(β-Glcp)-1-]n (n=3,4). In addition, this study was undertaken to determine the possible anticonvulsant and neuroprotective effects of GLOS (10-80 mg/kg) on kainic acid (KA)-induced seizures. The behavioral alterations and histopathology of hippocampal neurons were studied. Our results show that GLOS inhibited convulsions in rats from KA-induced seizures, reduced the degeneration pattern in the CA3 region of rats, decreased astrocytic reactivity, and reduced the expression of IL-1β and TNF-α induced by KA. These results indicate a potential anticonvulsant and neuroprotective effects of GLOS.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anticonvulsants / pharmacology
  • Anticonvulsants / therapeutic use*
  • Behavior, Animal / drug effects
  • Biological Products / isolation & purification
  • Biological Products / pharmacology
  • Biological Products / therapeutic use
  • Brain / drug effects*
  • Brain / metabolism
  • Brain / pathology
  • Drugs, Chinese Herbal / chemistry
  • Drugs, Chinese Herbal / pharmacology
  • Drugs, Chinese Herbal / therapeutic use*
  • Interleukin-1beta / metabolism
  • Kainic Acid
  • Male
  • Mycelium
  • Neuroprotective Agents / pharmacology
  • Neuroprotective Agents / therapeutic use*
  • Oligosaccharides / isolation & purification
  • Oligosaccharides / pharmacology
  • Oligosaccharides / therapeutic use*
  • Rats
  • Rats, Wistar
  • Reishi / chemistry*
  • Seizures / chemically induced
  • Seizures / drug therapy*
  • Seizures / metabolism
  • Seizures / pathology
  • Tumor Necrosis Factor-alpha / metabolism

Substances

  • Anticonvulsants
  • Biological Products
  • Drugs, Chinese Herbal
  • Interleukin-1beta
  • Neuroprotective Agents
  • Oligosaccharides
  • Tumor Necrosis Factor-alpha
  • Kainic Acid