Molecular diagnostics in the neoplasms of small intestine and appendix

Clin Lab Med. 2013 Dec;33(4):861-6. doi: 10.1016/j.cll.2013.08.007. Epub 2013 Oct 15.


Adenocarcinoma of the small intestine is relatively rare in comparison to colorectal carcinoma. Adenocarcinoma of the small intestine arises through the adenoma-carcinoma sequence in the colon. However, adenocarcinomas arising in the background of inflammatory bowel disease develop through the dysplasia-carcinoma sequence. Most of the cases occur in the duodenum; however, adenocarcinoma occurring in association with Crohn disease is more common in the ileum.

Keywords: Appendix; BRAF; KRAS; Microsatellite instability; Small intestine.

Publication types

  • Review

MeSH terms

  • Humans
  • Intestinal Neoplasms / diagnosis*
  • Intestine, Small* / pathology
  • Intestine, Small* / physiopathology
  • Molecular Diagnostic Techniques*