Beyond survival; influences of blood pressure, cerebral perfusion and anesthesia on neurodevelopment

Paediatr Anaesth. 2014 Jan;24(1):68-73. doi: 10.1111/pan.12310. Epub 2013 Nov 23.


Neonates have a higher perioperative mortality risk largely due to the degree of prior illness of the infants, the complexity of their surgeries, and infant physiology. It is important to consider contributing anesthetic factors during the perioperative period that may affect cerebral perfusion and neurocognitive outcome, such as alterations in hemodynamics and ventilation. Limitations of blood pressure as a marker for cerebral perfusion are discussed, as well as the effect of hypocapnia on the brain.

Keywords: blood pressure; general anesthesia; hypocapnia; ischemic encephalopathy; newborn infant; premature infant.

Publication types

  • Review

MeSH terms

  • Anesthesia / methods*
  • Blood Pressure / physiology*
  • Blood Pressure Determination
  • Brain Chemistry / physiology
  • Cerebrovascular Circulation / physiology*
  • Child Development
  • Homeostasis
  • Humans
  • Hypocapnia / blood
  • Hypocapnia / classification
  • Hypotension / complications
  • Hypotension / psychology
  • Infant, Newborn
  • Nervous System / growth & development*
  • Survival*