Naked replication forks break apRPArt

Cell. 2013 Nov 21;155(5):979-80. doi: 10.1016/j.cell.2013.10.049.

Abstract

Stalled replication forks occasionally collapse, leading to potentially catastrophic DNA double-strand breaks. Now, Toledo et al. (2013) reveal that fork breakage occurs when the pool of the single-strand DNA-binding protein RPA becomes exhausted. This study has important implications for the origin and treatment of cancers with high levels of replicative stress.

Publication types

  • Comment

MeSH terms

  • Ataxia Telangiectasia Mutated Proteins / metabolism
  • DNA Replication*
  • Genomic Instability*
  • Humans
  • Replication Protein A / metabolism*

Substances

  • RPA1 protein, human
  • Replication Protein A
  • ATR protein, human
  • Ataxia Telangiectasia Mutated Proteins