Efficacy of omega-3 in treatment of recurrent aphthous stomatitis and improvement of quality of life: a randomized, double-blind, placebo-controlled study

Oral Surg Oral Med Oral Pathol Oral Radiol. 2014 Feb;117(2):191-6. doi: 10.1016/j.oooo.2013.09.003. Epub 2013 Nov 21.

Abstract

Objective: This study assessed the effects of systemic omega-3 on the treatment of recurrent aphthous stomatitis and on the improvement of quality of life.

Study design: Fifty participants were randomly assigned to receive either omega-3 (1 g, 3 times daily) or placebo for 6 months. Assessment of outcome measures including monthly number of new ulcers, average duration of ulcer episodes, and pain level of ulcers was carried out at baseline and monthly for 6 months. Analysis of potential impact on quality of life using the Oral Health Impact Profile 14 was carried out at baseline and 6 months.

Results: Daily omega-3 treatment achieved a significant reduction in number of ulcers, duration of ulcers, and level of pain by 3 months that persisted for 6 months. Mean score on Oral Health Impact Profile 14 also significantly improved by 6 months.

Conclusions: A daily omega-3 regimen shows promise as therapy for treatment and management of patients with recurrent aphthous stomatitis.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Administration, Oral
  • Adult
  • Capsules
  • Double-Blind Method
  • Fatty Acids, Omega-3 / administration & dosage
  • Fatty Acids, Omega-3 / therapeutic use*
  • Female
  • Humans
  • Male
  • Placebos
  • Quality of Life*
  • Recurrence
  • Stomatitis, Aphthous / drug therapy*
  • Treatment Outcome

Substances

  • Capsules
  • Fatty Acids, Omega-3
  • Placebos