Destination: inner nuclear membrane

Trends Cell Biol. 2014 Apr;24(4):221-9. doi: 10.1016/j.tcb.2013.10.006. Epub 2013 Nov 19.


The inner nuclear membrane (INM) of eukaryotic cells is enriched in proteins that are required for nuclear structure, chromosome organization, DNA repair, and transcriptional control. Mislocalization of INM proteins is observed in a wide spectrum of human diseases; however, the mechanism by which INM proteins reach their final destination is poorly understood. In this review we discuss how investigating INM composition, dissecting targeting pathways of conserved INM proteins in multiple systems and analyzing the nuclear transport of viruses and signaling complexes have broadened our knowledge of INM transport to include both nuclear pore complex-dependent and -independent pathways. The study of these INM targeting pathways is important to understanding nuclear organization and in both normal and diseased cells.

Keywords: LEM domain; NPC; SUN protein; inner nuclear membrane; nuclear transport.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Active Transport, Cell Nucleus / physiology
  • Animals
  • Biosynthetic Pathways / physiology*
  • Humans
  • Membrane Proteins / metabolism*
  • Nuclear Envelope / metabolism*
  • Nuclear Pore Complex Proteins / metabolism*
  • Protein Binding / physiology


  • Membrane Proteins
  • Nuclear Pore Complex Proteins