Neuroprotection by astrocytes in brain ischemia: importance of microRNAs

Neurosci Lett. 2014 Apr 17;565:53-8. doi: 10.1016/j.neulet.2013.11.015. Epub 2013 Nov 19.


Astrocytes have been shown to protect neurons and increase their survival in many pathological settings. Manipulating astrocyte functions is thus an important strategy to enhance neuronal survival and improve outcome following cerebral ischemia. Increasing evidence supports the involvement of microRNAs (miRNA), some of them being astrocyte-enriched, in the regulation of cerebral ischemia. This mini review will focus on several recently reported astrocyte-enriched miRNAs (miR-181 and miR-29 families and miR-146a), their validated targets, regional expression and effects on outcome after cerebral ischemia.

Keywords: Astrocyte; Cerebral ischemia; miR-146a; miR-181; miR-29; microRNA.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Astrocytes / metabolism*
  • Astrocytes / pathology
  • Brain Ischemia / metabolism*
  • Brain Ischemia / pathology
  • Brain Ischemia / therapy
  • Cell Survival
  • Genetic Therapy
  • Humans
  • MicroRNAs / genetics
  • MicroRNAs / metabolism*
  • Neurons / pathology


  • MicroRNAs