The Search for ESR1 Mutations in Breast Cancer

Nat Genet. 2013 Dec;45(12):1415-6. doi: 10.1038/ng.2831.


Two new studies report the identification of activating ESR1 gene mutations in aromatase inhibitor-resistant metastatic breast cancers. This insight into therapeutic resistance suggests new approaches that may be useful in the management of endocrine-resistant breast cancer.

Publication types

  • News
  • Comment

MeSH terms

  • Animals
  • Antineoplastic Agents, Hormonal / therapeutic use*
  • Breast Neoplasms / drug therapy*
  • Breast Neoplasms / pathology*
  • Drug Resistance, Neoplasm / genetics*
  • Estrogen Receptor alpha / genetics*
  • Female
  • Humans
  • Mutation, Missense*
  • Protein Interaction Domains and Motifs / genetics*


  • Antineoplastic Agents, Hormonal
  • Estrogen Receptor alpha
  • estrogen receptor alpha, human