4-Acyl pyrroles: mimicking acetylated lysines in histone code reading

Angew Chem Int Ed Engl. 2013 Dec 23;52(52):14055-9. doi: 10.1002/anie.201307652. Epub 2013 Nov 24.
No abstract available

Keywords: 4-acyl pyrroles; bromodomain inhibition; drug discovery; epigenetics; virtual screening.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylation
  • Histone Code / genetics*
  • Histones / genetics*
  • Histones / metabolism
  • Humans
  • Lysine / genetics*
  • Pyrroles / metabolism*

Substances

  • Histones
  • Pyrroles
  • Lysine