Acute focal bacterial nephritis due to methicillin-resistant Staphylococcus aureus in an immunocompetent adult

Infection. 2014 Apr;42(2):433-6. doi: 10.1007/s15010-013-0553-5. Epub 2013 Nov 25.


Acute focal bacterial nephritis (AFBN) is a rare, acute focal infection of the renal parenchyma without liquefaction. The pathogenesis is thought to be due to hematogenous infection or ascending infection from the lower urinary tract. Escherichia coli has been the major pathogen isolated in prior cases, but other Gram-negative enteric pathogens and Staphylococcus aureus have been reported as well. It is well described in children and adults with diabetes and organ transplantation, but has not been previously reported in healthy adults. We report a case of an immunocompetent adult female who presented with a methicillin-resistant Staphylococcus aureus bacteremia after a skin and soft tissue infection that resulted in AFBN.

Publication types

  • Case Reports

MeSH terms

  • Acute Disease
  • Adult
  • Anti-Bacterial Agents / pharmacology
  • Anti-Bacterial Agents / therapeutic use*
  • Daptomycin / pharmacology
  • Daptomycin / therapeutic use*
  • Female
  • Humans
  • Methicillin-Resistant Staphylococcus aureus / drug effects
  • Methicillin-Resistant Staphylococcus aureus / isolation & purification
  • Nephritis / drug therapy*
  • Nephritis / microbiology
  • Nephritis / pathology
  • Skin Diseases, Bacterial / complications
  • Skin Diseases, Bacterial / drug therapy
  • Skin Diseases, Bacterial / pathology
  • Soft Tissue Infections / complications
  • Soft Tissue Infections / drug therapy
  • Soft Tissue Infections / pathology
  • Staphylococcal Infections / drug therapy*
  • Staphylococcal Infections / microbiology
  • Staphylococcal Infections / pathology
  • Treatment Outcome


  • Anti-Bacterial Agents
  • Daptomycin