Metal-free, acid-promoted synthesis of imidazole derivatives via a multicomponent reaction

Org Lett. 2013 Dec 20;15(24):6116-9. doi: 10.1021/ol402892z. Epub 2013 Nov 26.

Abstract

An expedient and metal-free synthetic route has been developed for the construction of tri- and tetrasubstituted imidazole derivatives via acid promoted multicomponent reaction methodology. The reaction proceeded smoothly with a range of functionalities to produce the imidazole scaffolds in good to excellent yields.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acids / chemistry*
  • Imidazoles / chemical synthesis*
  • Imidazoles / chemistry
  • Molecular Structure

Substances

  • Acids
  • Imidazoles
  • imidazole