[Profilins: allergens with clinical relevance]

Rev Alerg Mex. Jul-Sep 2013;60(3):129-43.
[Article in Spanish]

Abstract

Introduction: Profilins are small ubiquitous proteins of 12-19 kDa involved in actin dynamics. These proteins are found in all eukaryotic organisms studied to date. Profilins have aminoacid sequences and tridimensional structure highly conserved. Allergy patients to pollen frequently have symptoms of allergy when ingestion of plant-derived foods like fruits, vegetables, seeds, among others. This phenomenon is known as latex-pollen-fruit allergy and it's the main cause of oral allergy syndrome (OAS) which is attributed to the cross-reactivity. Allergens shared between different sources theses are called panallergens for example are profilins which representing at least 20% of all pollen allergic patients. This cross-reactivity is results from the high amino acid sequence identity of profilin from plants, which is between 70% and 85%, this may explain the exacerbation symptoms of allergic patients to profilins from plants.

Objective: We described some characteristics which show us the important participation of the profilins in the sensitization of people allergic, especially to plants, fruits and pollen.

Methods: We looked research aminoacid sequences of all allergenic profilins reported to date and these were analyzed.

Conclusions: Profilins are important allergens that are underrated in clinical practice and contribute to cross-reactivity in sensitized individuals by profilins from other sources.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Allergens* / genetics
  • Gene Expression Regulation
  • Humans
  • Hypersensitivity / immunology*
  • Molecular Conformation
  • Profilins* / genetics

Substances

  • Allergens
  • Profilins