Future trends for unicompartmental arthritis of the knee: injectables & stem cells

Clin Sports Med. 2014 Jan;33(1):161-74. doi: 10.1016/j.csm.2013.06.006. Epub 2013 Jul 19.


Arthritis is one of the most frequent musculoskeletal problems, causing pain, disability, and a significant economic burden. In this article, we discuss current nonsurgical injectable treatment options as well as future trends for cartilage lesions and early arthritis of the knee. We cover some potential treatments for knee osteoarthritis, including stem cell and gene therapies.

Keywords: Arthritis; Hyaluronic acid; Injectable arthritis treatment; Knee arthritis; Osteoarthritis; Stem cell.

Publication types

  • Review

MeSH terms

  • Adrenal Cortex Hormones / therapeutic use*
  • Anti-Inflammatory Agents / therapeutic use*
  • Combined Modality Therapy
  • Genetic Therapy / methods
  • Genetic Therapy / trends*
  • Humans
  • Hyaluronic Acid / therapeutic use
  • Injections, Intra-Articular
  • Intercellular Signaling Peptides and Proteins / therapeutic use*
  • Osteoarthritis, Knee / therapy*
  • Platelet-Rich Plasma
  • Stem Cell Transplantation / methods
  • Stem Cell Transplantation / trends*
  • Viscosupplementation / methods
  • Viscosupplementation / trends*
  • Viscosupplements / therapeutic use


  • Adrenal Cortex Hormones
  • Anti-Inflammatory Agents
  • Intercellular Signaling Peptides and Proteins
  • Viscosupplements
  • Hyaluronic Acid