Obesity and liver disease: the epidemic of the twenty-first century

Clin Liver Dis. 2014 Feb;18(1):1-18. doi: 10.1016/j.cld.2013.09.019.


Obesity is a rapidly growing health problem that is associated with more than 65 comorbidities and results in substantially increased all-cause mortality. The increase of obesity has played an important role in the increasing prevalence of nonalcoholic fatty liver disease (NAFLD), the most common cause of liver disease in the United States. Understanding the prevalence, comorbidities, and pathogenesis of obesity provides an essential foundation for clinicians who care for individuals with NAFLD.

Keywords: Cirrhosis; Energy balance; Fat mass; Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis; Obesity; Weight loss.

Publication types

  • Historical Article
  • Review

MeSH terms

  • Carcinoma, Hepatocellular / etiology
  • Epidemics
  • Fatty Liver / etiology
  • Gastrointestinal Tract / microbiology
  • Gastrointestinal Tract / physiopathology
  • Hepatitis C, Chronic / etiology
  • History, 21st Century
  • Humans
  • Liver Diseases / epidemiology
  • Liver Diseases / etiology*
  • Liver Neoplasms / etiology
  • Microbiota
  • Non-alcoholic Fatty Liver Disease
  • Obesity / complications*
  • Obesity / epidemiology
  • Obesity / therapy
  • Risk Factors
  • United States / epidemiology