Obesity-associated nonalcoholic fatty liver disease

Clin Liver Dis. 2014 Feb;18(1):19-31. doi: 10.1016/j.cld.2013.09.018. Epub 2013 Oct 24.


Obesity is strongly associated with the prevalence of nonalcoholic fatty liver disease (NAFLD) in adult and pediatric populations. Nutrition, physical activity, and behavioral modifications are critical components of the treatment regimen for all obese patients with NAFLD. Bariatric surgeries that affect or restrict the flow of food through the gastrointestinal tract may improve liver histology in morbidly obese patients with nonalcoholic steatohepatitis (NASH), although randomized clinical trials and quasi-randomized clinical studies are lacking. Early detection of NASH and hepatic fibrosis using noninvasive biochemical and imaging markers that may replace liver biopsy is the current challenge.

Keywords: Epidemiology; Nonalcoholic fatty liver disease; Obesity; Pathophysiology.

Publication types

  • Review

MeSH terms

  • Adult
  • Bariatric Surgery
  • Child
  • Fatty Liver / epidemiology
  • Fatty Liver / etiology*
  • Fatty Liver / therapy
  • Female
  • Humans
  • Insulin Resistance
  • Lipase / genetics
  • Male
  • Membrane Proteins / genetics
  • Non-alcoholic Fatty Liver Disease
  • Obesity / complications*
  • Obesity / epidemiology
  • Obesity / therapy
  • Polymorphism, Single Nucleotide
  • Risk Factors


  • Membrane Proteins
  • Lipase
  • adiponutrin, human