The impact of obesity and metabolic syndrome on alcoholic liver disease

doi:10.1016/j.cld.2013.09.006

Review

. 2014 Feb;18(1):157-63.

doi: 10.1016/j.cld.2013.09.006. Epub 2013 Oct 24.

The impact of obesity and metabolic syndrome on alcoholic liver disease

Dian J Chiang¹, Arthur J McCullough

Affiliations

PMID: 24274871
PMCID: PMC6130318
DOI: 10.1016/j.cld.2013.09.006

Review

The impact of obesity and metabolic syndrome on alcoholic liver disease

Dian J Chiang et al. Clin Liver Dis. 2014 Feb.

. 2014 Feb;18(1):157-63.

doi: 10.1016/j.cld.2013.09.006. Epub 2013 Oct 24.

Authors

Dian J Chiang¹, Arthur J McCullough

Affiliation

¹ Department of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic, A51, 9500 Euclid Avenue, Cleveland, OH 44195, USA.

PMID: 24274871
PMCID: PMC6130318
DOI: 10.1016/j.cld.2013.09.006

Abstract

Alcoholic liver disease (ALD) remains a major cause of chronic liver diseases and liver failure. Population-based prospective studies and patient cohort studies have demonstrated that obesity and the metabolic syndrome exacerbate progression of ALD and increase hepatocellular carcinoma (HCC) incidence and mortality. Emerging evidence also suggests a synergism between alcohol and obesity in mortality and HCC incidence. Recognition of these increased risks and detection of early-stage liver disease may offer the opportunity to address these modifiable risk factors and prevent disease progression in these patients.

Keywords: Alcoholic liver disease; Diabetes; Insulin resistance; Metabolic syndrome; Obesity.

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References

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[1] Mandayam S, Jamal MM, Morgan TR. Epidemiology of alcoholic liver disease. Seminars in liver disease. August 2004;24(3):217–232. - PubMed

[2] Mandayam S, Jamal MM, Morgan TR. Epidemiology of alcoholic liver disease. Seminars in liver disease. August 2004;24(3):217–232. - PubMed

[3] Peery AF, Dellon ES, Lund J, et al. Burden of gastrointestinal disease in the United States: 2012 update. Gastroenterology November 2012;143(5):1179–1187 e1171–1173. - PMC - PubMed

[4] Peery AF, Dellon ES, Lund J, et al. Burden of gastrointestinal disease in the United States: 2012 update. Gastroenterology November 2012;143(5):1179–1187 e1171–1173. - PMC - PubMed

[5] Mann RE, Smart RG, Govoni R. The epidemiology of alcoholic liver disease. Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism. 2003;27(3):209–219. - PMC - PubMed

[6] Mann RE, Smart RG, Govoni R. The epidemiology of alcoholic liver disease. Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism. 2003;27(3):209–219. - PMC - PubMed

[7] Corrao G, Ferrari P, Zambon A, Torchio P. Are the recent trends in liver cirrhosis mortality affected by the changes in alcohol consumption? Analysis of latency period in European countries. Journal of studies on alcohol. September 1997;58(5):486–494. - PubMed

[8] Corrao G, Ferrari P, Zambon A, Torchio P. Are the recent trends in liver cirrhosis mortality affected by the changes in alcohol consumption? Analysis of latency period in European countries. Journal of studies on alcohol. September 1997;58(5):486–494. - PubMed

[9] Kim WR, Brown RS, Jr., Terrault NA, El-Serag H. Burden of liver disease in the United States: summary of a workshop. Hepatology (Baltimore, Md. July 2002;36(1):227–242. - PubMed

[10] Kim WR, Brown RS, Jr., Terrault NA, El-Serag H. Burden of liver disease in the United States: summary of a workshop. Hepatology (Baltimore, Md. July 2002;36(1):227–242. - PubMed

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The impact of obesity and metabolic syndrome on alcoholic liver disease

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The impact of obesity and metabolic syndrome on alcoholic liver disease

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