New insights into the cell lineage of pancreatic ductal adenocarcinoma: evidence for tumor stem cells in premalignant lesions?

Gastroenterology. 2014 Jan;146(1):24-6. doi: 10.1053/j.gastro.2013.11.023. Epub 2013 Nov 22.
No abstract available

Publication types

  • Editorial
  • Comment

MeSH terms

  • Animals
  • Bile Ducts / cytology*
  • Carcinoma in Situ / metabolism*
  • Carcinoma, Pancreatic Ductal / metabolism*
  • Carcinoma, Pancreatic Ductal / pathology*
  • Cell Transformation, Neoplastic / pathology*
  • HMGB Proteins / metabolism*
  • Humans
  • Intracellular Signaling Peptides and Proteins / metabolism*
  • Pancreatic Ducts / pathology*
  • Pancreatic Neoplasms / metabolism*
  • Pancreatic Neoplasms / pathology*
  • Precancerous Conditions / pathology*
  • Protein-Serine-Threonine Kinases / metabolism*
  • SOXF Transcription Factors / metabolism*
  • Stem Cells / metabolism*

Substances

  • HMGB Proteins
  • Intracellular Signaling Peptides and Proteins
  • SOXF Transcription Factors
  • Sox17 protein, mouse
  • DCLK1 protein, human
  • Dclk1 protein, mouse
  • Protein-Serine-Threonine Kinases