Glomerular disease: the role of parietal epithelial cells in hyperplastic lesions

Nat Rev Nephrol. 2014 Jan;10(1):5-6. doi: 10.1038/nrneph.2013.252. Epub 2013 Nov 26.


Parietal epithelial cells (PECs) are increasingly recognized as key players in the pathogenesis of proliferative glomerular diseases. A new study by Rizzo and colleagues contributes to this emerging concept and identifies potential novel signalling pathways that might mediate the activation of PECs. However, the functional role of PECs remains controversial.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Cell Proliferation*
  • Epithelial Cells*
  • Female
  • Glomerular Mesangium*
  • Glomerulonephritis*
  • Humans
  • Inflammation Mediators / metabolism*
  • Male
  • Stem Cells*


  • Inflammation Mediators