Abstract
The FACT histone chaperone/nucleosome reorganization factor plays key roles in nucleosome dynamics during transcription. A new study has linked a specific domain in the H2B N terminus to the activity of FACT in regulating nucleosome disassembly at promoters during transcription activation and nucleosome reassembly at coding regions during transcription elongation.
MeSH terms
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DNA-Binding Proteins / metabolism*
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High Mobility Group Proteins / metabolism*
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Histones / metabolism*
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Humans
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Nucleosomes / metabolism*
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Saccharomyces cerevisiae Proteins / metabolism*
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Transcriptional Elongation Factors / metabolism*
Substances
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DNA-Binding Proteins
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FACT protein, S cerevisiae
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High Mobility Group Proteins
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Histones
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Nucleosomes
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Saccharomyces cerevisiae Proteins
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Transcriptional Elongation Factors