FACT and the H2B N tail

Mol Cell Biol. 2014 Feb;34(3):300-2. doi: 10.1128/MCB.01519-13. Epub 2013 Nov 25.

Abstract

The FACT histone chaperone/nucleosome reorganization factor plays key roles in nucleosome dynamics during transcription. A new study has linked a specific domain in the H2B N terminus to the activity of FACT in regulating nucleosome disassembly at promoters during transcription activation and nucleosome reassembly at coding regions during transcription elongation.

Publication types

  • Comment

MeSH terms

  • DNA-Binding Proteins / metabolism*
  • High Mobility Group Proteins / metabolism*
  • Histones / metabolism*
  • Humans
  • Nucleosomes / metabolism*
  • Saccharomyces cerevisiae Proteins / metabolism*
  • Transcriptional Elongation Factors / metabolism*

Substances

  • DNA-Binding Proteins
  • FACT protein, S cerevisiae
  • High Mobility Group Proteins
  • Histones
  • Nucleosomes
  • Saccharomyces cerevisiae Proteins
  • Transcriptional Elongation Factors