Does Kawasaki disease have a retroviral aetiology?

Lancet. 1986 Sep 6;2(8506):545-6. doi: 10.1016/s0140-6736(86)90115-7.

Abstract

In 18 consecutive children with Kawasaki disease of recent onset, reverse transcriptase (RT) activity was studied in co-cultivated peripheral-blood-mononuclear-cell/lymphoblastoid-cell supernatants. 8 of 18 children, but only 1 of 18 controls, showed RT activity in one or more sample (p = 0.009). RT activity was identified in 14 of 226 samples from patients, but in only 1 of 167 from controls (p less than 0.01). The findings suggest that a retroviral agent may be casually related to Kawasaki disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acute Disease
  • Adolescent
  • Child
  • Child, Preschool
  • Humans
  • Infant
  • Methods
  • Mucocutaneous Lymph Node Syndrome / etiology*
  • RNA-Directed DNA Polymerase / blood
  • Retroviridae Infections / complications*

Substances

  • RNA-Directed DNA Polymerase