Low high-density lipoprotein cholesterol is characterized by elevated oxidative stress

Angiology. 2014 Nov;65(10):927-31. doi: 10.1177/0003319713512173. Epub 2013 Nov 25.


High-density lipoprotein cholesterol (HDL-C) is an independent risk factor for premature atherosclerosis and cardiovascular disease. Plasma HDL exerts potent antioxidant activity. We evaluated parameters associated with oxidative stress in participants with low HDL-C. This study included 32 patients with low HDL-C (≤35 mg/dL) and 33 age- and sex-matched control patients with normal HDL-C (>35 mg/dL). We evaluated clinical and laboratory parameters that are associated with oxidative stress. The oxidative stress index (OSI) levels were significantly higher in the low HDL-C group (3.32 [0.01-13.3] vs 0.74 [0.17-3.55] AU; P<.01) and negatively correlated with HDL-C levels. We suggest that change in OSI and uric acid levels in the study group might indicate increased oxidative status in patients with low HDL-C. This may be associated with increased cardiovascular risk.

Keywords: high-density lipoprotein; oxidative stress; oxidative stress index.

MeSH terms

  • Biomarkers / blood
  • Body Mass Index
  • Cardiovascular Diseases / blood*
  • Case-Control Studies
  • Female
  • Humans
  • Lipoproteins, HDL / blood
  • Lipoproteins, LDL / blood*
  • Male
  • Middle Aged
  • Oxidative Stress*
  • Risk Factors
  • Uric Acid / blood


  • Biomarkers
  • Lipoproteins, HDL
  • Lipoproteins, LDL
  • Uric Acid