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. 2010 May 7;2(2):794-808.
doi: 10.3390/cancers2020794.

Cytokines and growth factors expressed by human cutaneous melanoma

Elias G Elias  1 , Joanne H Hasskamp, Bhuvnesh K Sharma
Affiliations
Free PMC article

Cytokines and growth factors expressed by human cutaneous melanoma

Elias G Elias et al. Cancers (Basel). .
Free PMC article

Abstract

Cytokines and growth factors have biologic effects that could stimulate tumor growth, invasion and angiogenesis. The incidence of 24 factors was investigated in 25 cultured human melanoma cell lines and in 62 fixed tissues at different stages of the disease. Over 80% of the human melanoma cell lines expressed TGF-β, IL-8, IL-6, VEGF, PDGF-AA and OPN. Significantly higher TGF-β, IGF-1 and IL-15 were determined in primary lesions compared to distant metastases by immunohistochemistry. Illustrating the complexity of the milieu of the tumor microenvironment, some of these factors may have to be considered in targeted therapy.

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Figures

Figure 1
Figure 1
Images of representative IHC staining for factors in primary melanoma (A) and metastatic melanoma (B).
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