A dendritic thioester hydrogel based on thiol-thioester exchange as a dissolvable sealant system for wound closure

Angew Chem Int Ed Engl. 2013 Dec 23;52(52):14070-4. doi: 10.1002/anie.201308007. Epub 2013 Nov 26.


A dissolvable dendritic thioester hydrogel based on thiol-thioester exchange for wound closure is reported. The hydrogel sealant adheres strongly to tissues, closes an ex vivo vein puncture, and withstands high pressures placed on a wound. The hydrogel sealant can be completely washed off upon exposure to thiolates based on thiol-thioester exchange and allow gradual wound re-exposure during definitive surgical care.

Keywords: dendrimers; hemostasis; hydrogels; supramolecular chemistry; wound dressing.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Dendrimers / chemistry*
  • Esters / chemistry*
  • Hemostasis
  • Humans
  • Hydrogel, Polyethylene Glycol Dimethacrylate
  • Hydrogels
  • Sulfhydryl Compounds / chemistry*
  • Wound Closure Techniques*


  • Dendrimers
  • Esters
  • Hydrogels
  • Sulfhydryl Compounds
  • Hydrogel, Polyethylene Glycol Dimethacrylate