Pulmonary drug toxicity: presentation of a case of recurrent diffuse alveolar damage caused by paroxetine

Am J Ther. Mar-Apr 2015;22(2):e43-7. doi: 10.1097/MJT.0b013e31829ed1f2.


Pulmonary drug toxicity is being diagnosed more often as a cause of acute and chronic lung disease. Numerous agents including cytotoxic and noncytotoxic drugs have the potential to cause pulmonary toxicity. Recurrent diffuse alveolar damage is a rare manifestation of drug toxicity. We described an extremely rare case of recurrent diffuse alveolar damage caused by the antidepressant drug (paroxetine) resolved by a definitive suspension of the drug, after a recurrent respiratory failure because of inadvertently administering the drug.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antidepressive Agents, Second-Generation / adverse effects
  • Female
  • Humans
  • Paroxetine / adverse effects*
  • Pulmonary Alveoli / drug effects*
  • Pulmonary Alveoli / pathology
  • Recurrence
  • Respiratory Insufficiency / chemically induced*
  • Respiratory Insufficiency / physiopathology


  • Antidepressive Agents, Second-Generation
  • Paroxetine