Severe demodexfolliculorum-associated oculocutaneous rosacea in a girl successfully treated with ivermectin

JAMA Dermatol. 2014 Jan;150(1):61-3. doi: 10.1001/jamadermatol.2013.7688.

Abstract

Importance: There is a limited therapeutic armamentarium for recalcitrant cases of childhood rosacea.

Observations: We report the case of a 12-year-old girl who presented with severe ocular and cutaneous rosacea unresponsive to oral doxycycline, oral isotretinoin, and topical tacrolimus. A biopsy specimen showed numerous mites within the folliculosebaceous unit. Treatment with a single dose of oral ivermectin achieved resolution of her symptoms.

Conclusions and relevance: The causative role of Demodex folliculorum should be considered in immunocompetent children with rosacea or rosacea-like refractory eruptions. In such cases, treatment with ivermectin can be beneficial.

Publication types

  • Case Reports

MeSH terms

  • Animals
  • Antiparasitic Agents / administration & dosage
  • Antiparasitic Agents / therapeutic use
  • Child
  • Eye Infections, Parasitic / diagnosis*
  • Eye Infections, Parasitic / drug therapy
  • Eye Infections, Parasitic / parasitology
  • Female
  • Humans
  • Ivermectin / administration & dosage
  • Ivermectin / therapeutic use
  • Mite Infestations / diagnosis*
  • Mite Infestations / drug therapy
  • Mite Infestations / parasitology
  • Rosacea / diagnosis*
  • Rosacea / drug therapy
  • Rosacea / parasitology
  • Severity of Illness Index
  • Skin Diseases, Parasitic / diagnosis*
  • Skin Diseases, Parasitic / drug therapy
  • Skin Diseases, Parasitic / parasitology
  • Treatment Outcome

Substances

  • Antiparasitic Agents
  • Ivermectin