The chromosome-centric human proteome project at FEBS Congress

Proteomics. 2014 Feb;14(2-3):147-52. doi: 10.1002/pmic.201300373.


In the summer of 2013, distinguished global representatives of proteome science gathered to discuss the futuristic visions of the chromosome-centric human proteome project (C-HPP) (Cochairs: Y. K. Paik, G. Omenn; hosted by A. Archakov, Institute of Biomedical Chemistry, Russia) that was broadcast to the annual Federation of European Biochemical Societies Congress (St. Petersburg, Russia, July 10-11, 2013). Technology breakthroughs presented included a new ultra-sensitive Tribrid mass-spectrometer from Thermo and SOMAmers-Slow Off-rate Modified Aptamers (SOMAlogic, USA), a new type of protein capture reagents. Professor Archakov's group introduced the "rectangle" concept of proteome size as a product of proteome width and depth. The discussion on proteome width culminated with the introduction of digital biomarkers-low-copied aberrant proteins that differ from their typical forms by PTMs, alternative splicing, or single amino acid polymorphisms. The aberrant proteoforms, a complement to whole-genome proteomic surveys, were presented as an ultimate goal for the proteomic community.

Keywords: Digital biomarkers; Human Proteome Project; Proteome depth; Proteome width; Technology.

Publication types

  • Congress
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chromosomes, Human / genetics*
  • Human Genome Project*
  • Humans
  • Mass Spectrometry / methods
  • Proteome / analysis
  • Proteome / genetics*
  • Proteomics / methods*
  • Russia


  • Proteome