Transient receptor potential (TRP) channels in the airway: role in airway disease

Br J Pharmacol. 2014 May;171(10):2593-607. doi: 10.1111/bph.12538.


Over the last few decades, there has been an explosion of scientific publications reporting the many and varied roles of transient receptor potential (TRP) ion channels in physiological and pathological systems throughout the body. The aim of this review is to summarize the existing literature on the role of TRP channels in the lungs and discuss what is known about their function under normal and diseased conditions. The review will focus mainly on the pathogenesis and symptoms of asthma and chronic obstructive pulmonary disease and the role of four members of the TRP family: TRPA1, TRPV1, TRPV4 and TRPM8. We hope that the article will help the reader understand the role of TRP channels in the normal airway and how their function may be changed in the context of respiratory disease.

Keywords: COPD; TRP channels; airway; asthma.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Anti-Asthmatic Agents / pharmacology
  • Asthma / drug therapy
  • Asthma / metabolism*
  • Asthma / physiopathology
  • Humans
  • Ligands
  • Lung / drug effects
  • Lung / metabolism*
  • Lung / physiopathology
  • Membrane Transport Modulators / pharmacology
  • Pulmonary Disease, Chronic Obstructive / drug therapy
  • Pulmonary Disease, Chronic Obstructive / metabolism*
  • Pulmonary Disease, Chronic Obstructive / physiopathology
  • Signal Transduction
  • Transient Receptor Potential Channels / drug effects
  • Transient Receptor Potential Channels / metabolism*


  • Anti-Asthmatic Agents
  • Ligands
  • Membrane Transport Modulators
  • Transient Receptor Potential Channels