Substance P in heart failure: the good and the bad

Int J Cardiol. 2014 Jan 1;170(3):270-7. doi: 10.1016/j.ijcard.2013.11.010. Epub 2013 Nov 12.


The tachykinin, substance P, is found primarily in sensory nerves. In the heart, substance P-containing nerve fibers are often found surrounding coronary vessels, making them ideally situated to sense changes in the myocardial environment. Recent studies in rodents have identified substance P as having dual roles in the heart, depending on disease etiology and/or timing. Thus far, these studies indicate that substance P may be protective acutely following ischemia-reperfusion, but damaging long-term in non-ischemic induced remodeling and heart failure. Sensory nerves may be at the apex of the cascade of events leading to heart failure, therefore, they make a promising potential therapeutic target that warrants increased investigation.

Keywords: Heart failure; Myocardial remodeling; Neuropeptide; Sensory nerve; Substance P; Tachykinin.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Heart / innervation
  • Heart / physiology*
  • Heart Failure / physiopathology*
  • Humans
  • Sensory Receptor Cells / physiology
  • Substance P / physiology*
  • Ventricular Remodeling / physiology*


  • Substance P