Diabetic neuropathy

Endocrinol Metab Clin North Am. 2013 Dec;42(4):747-87. doi: 10.1016/j.ecl.2013.06.001.


Diabetic neuropathy (DN) is the most common and troublesome complication of diabetes mellitus, leading to the greatest morbidity and mortality and resulting in a huge economic burden for diabetes care. The clinical assessment of diabetic peripheral neuropathy and its treatment options are multifactorial. Patients with DN should be screened for autonomic neuropathy, as there is a high degree of coexistence of the two complications. A review of the clinical assessment and treatment algorithms for diabetic neuropathy, painful neuropathy, and autonomic dysfunction is provided.

Keywords: Diabetes mellitus; Diabetic nephropathy; Painful neuropathy; Pregabalin.

Publication types

  • Review

MeSH terms

  • Autonomic Nervous System Diseases / etiology
  • Autonomic Nervous System Diseases / therapy
  • Cardiovascular Diseases / complications
  • Cardiovascular Diseases / pathology
  • Diabetic Neuropathies / diagnosis
  • Diabetic Neuropathies / epidemiology
  • Diabetic Neuropathies / mortality
  • Diabetic Neuropathies / pathology
  • Diabetic Neuropathies / therapy*
  • Guidelines as Topic
  • Humans
  • Hyperglycemia / complications
  • Hyperglycemia / pathology
  • Neuralgia / drug therapy
  • Neuralgia / epidemiology
  • Neuralgia / etiology