The radiosensitivity of cultured human and mouse keratinocytes

Int J Radiat Biol Relat Stud Phys Chem Med. 1986 Oct;50(4):717-26. doi: 10.1080/09553008614551111.

Abstract

Clonogenic survival assays after gamma-radiation in vitro were performed on freshly isolated and subcultured keratinocytes from mouse skin, mouse tongue and human skin. Survival curves were constructed by fitting the data to a multi-target model of cell survival. When subcultured, keratinocytes from all sites produced survival curves which showed a reduced shoulder region and an increased D0 when compared with their freshly isolated counterparts. Freshly isolated human skin keratinocytes were more radiosensitive than mouse keratinocytes from either skin or tongue.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Epidermal Cells*
  • Humans
  • Keratins / radiation effects*
  • Mice
  • Radiation Tolerance
  • Skin / radiation effects
  • Tongue / radiation effects

Substances

  • Keratins