Perfluoroalkanesulfonamide Organocatalysts for Asymmetric Conjugate Additions of Branched Aldehydes to Vinyl Sulfones

Molecules. 2013 Nov 25;18(12):14529-42. doi: 10.3390/molecules181214529.

Abstract

Asymmetric conjugate additions of branched aldehydes to vinyl sulfones promoted by sulfonamide organocatalyst 6 or 7 have been developed, allowing facile synthesis of the corresponding adducts with all-carbon quaternary stereocenters in excellent yields with up to 95% ee.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldehydes / chemistry*
  • Catalysis
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Sulfonamides / chemistry*
  • Sulfones / chemistry*

Substances

  • Aldehydes
  • Sulfonamides
  • Sulfones
  • divinyl sulfone