Immunomodulating effect of ethyl pyruvate on nonsyngenic transplanted tumor in mice

Bull Exp Biol Med. 2013 Oct;155(6):785-7. doi: 10.1007/s10517-013-2252-8.


Indolamine-2,3-dioxygenase, a tryptophan-catabolizing enzyme, creates local conditions suppressing immune lymphocytes. Expression of this enzyme in tumors protects them from immune mechanisms, while its inhibition partially reduces tumor immunoresistance. This effect is attained by multiple subcutaneous or intraperitoneal injections of ethyl pyruvate, an indolamine-2,3-dioxygenase inhibitor. Experiments on mouse nonsyngenic tumor have demonstrated the immunomodulating effect of chronic oral ethyl pyruvate administered with drinking water.

MeSH terms

  • Animals
  • Antineoplastic Agents / pharmacology*
  • Cell Line, Tumor
  • Drug Screening Assays, Antitumor
  • Female
  • Immunologic Factors / pharmacology*
  • Male
  • Mice
  • Mice, Inbred C3H
  • Neoplasm Transplantation
  • Neoplasms, Experimental / drug therapy
  • Neoplasms, Experimental / immunology
  • Neoplasms, Experimental / pathology
  • Pyruvates / pharmacology*
  • Tumor Burden / drug effects
  • Tumor Escape / drug effects


  • Antineoplastic Agents
  • Immunologic Factors
  • Pyruvates
  • ethyl pyruvate