Lack of association between brain-derived neurotrophic factor Val66Met polymorphism and aggressive behavior in schizophrenia

Psychiatry Res. 2014 Jan 30;215(1):244-5. doi: 10.1016/j.psychres.2013.10.017. Epub 2013 Nov 7.

Abstract

We investigated the association of the Val66Met gene polymorphism in the Brain-Derived Neurotrophic Factor (BDNF) gene with aggressive behavior among Southern Han Chinese schizophrenia patients. We used polymerase chain reaction-restriction fragment length polymorphism to determine the genotypes and the Modified Overt Aggression Scale (MOAS) to measure aggressive behavior. No significant differences in genotype or allele distribution of Val66Met were identified between aggressive and non-aggressive schizophrenia patients.

Keywords: Aggression; Genetic association; Modified Overt Aggression Scale (MOAS).

MeSH terms

  • Adolescent
  • Adult
  • Aggression / physiology*
  • Aggression / psychology
  • Alleles
  • Asian People / genetics
  • Brain-Derived Neurotrophic Factor / genetics*
  • Female
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide*
  • Schizophrenia / genetics*
  • Schizophrenic Psychology*
  • Young Adult

Substances

  • Brain-Derived Neurotrophic Factor