The antibacterial activity of geranium oil against Gram-negative bacteria isolated from difficult-to-heal wounds

Burns. 2014 Aug;40(5):1046-51. doi: 10.1016/j.burns.2013.11.002. Epub 2013 Nov 28.


Hard-to-heal wounds represent a significant problem to patients, health care professionals, and health care system. They can be formed as a result of mechanical injuries and burns, and any co-existing chronic disease increases the risk of their emergence. Diabetics are at a greater risk of developing chronic wounds because of poor circulation, slow healing times, vascular disease and neuropathy. The aim of this study was to determine the antimicrobial activity of geranium oil against Gram-negative bacterial clinical strains. Clinical strains were isolated from patients with difficult-to-treat wounds and a comprehensive evaluation of their sensitivity to antibiotics was carried out. The constituents of geranium oil were specified by GC-FID-MS analysis. The micro-dilution broth method was used to check the inhibition of microbial growth at various concentrations of geranium oil. The tested geranium oil was efficacious against Gram-negative pathogens responsible for problems with wound treatment. The results suggest that geranium oil may be considered an effective component of therapy in the case of frequent recurrences of infections caused by resistant pathogens.

Keywords: Geranium oil; Gram-negative pathogens; Inhibiting activity; Wounds.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Citrobacter freundii / drug effects*
  • Citrobacter freundii / isolation & purification
  • Cronobacter sakazakii / drug effects*
  • Cronobacter sakazakii / isolation & purification
  • Enterobacter cloacae / drug effects*
  • Enterobacter cloacae / isolation & purification
  • Escherichia coli / drug effects*
  • Escherichia coli / isolation & purification
  • Female
  • Geranium*
  • Humans
  • Male
  • Microbial Sensitivity Tests
  • Middle Aged
  • Oils, Volatile / pharmacology*
  • Proteus mirabilis / drug effects*
  • Proteus mirabilis / isolation & purification
  • Pseudomonas aeruginosa / drug effects*
  • Pseudomonas aeruginosa / isolation & purification
  • Wound Infection / microbiology*


  • Oils, Volatile