An oxalyl-CoA synthetase is important for oxalate metabolism in Saccharomyces cerevisiae

FEBS Lett. 2014 Jan 3;588(1):160-6. doi: 10.1016/j.febslet.2013.11.026. Epub 2013 Nov 26.


Although oxalic acid is common in nature our understanding of the mechanism(s) regulating its turnover remains incomplete. In this study we identify Saccharomyces cerevisiae acyl-activating enzyme 3 (ScAAE3) as an enzyme capable of catalyzing the conversion of oxalate to oxalyl-CoA. Based on our findings we propose that ScAAE3 catalyzes the first step in a novel pathway of oxalate degradation to protect the cell against the harmful effects of oxalate derived from an endogenous process or an environmental source.

Keywords: Acyl-activating; Degradation; Oxalate; Oxalyl-CoA.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Acyl Coenzyme A / metabolism*
  • Carbon Dioxide / metabolism
  • Coenzyme A Ligases / genetics
  • Coenzyme A Ligases / metabolism*
  • Gene Expression Regulation, Developmental
  • Gene Expression Regulation, Fungal
  • Hydrogen-Ion Concentration
  • Kinetics
  • Models, Biological
  • Mutation
  • Oxalates / metabolism*
  • Reverse Transcriptase Polymerase Chain Reaction
  • Saccharomyces cerevisiae / genetics
  • Saccharomyces cerevisiae / growth & development
  • Saccharomyces cerevisiae / metabolism*
  • Saccharomyces cerevisiae Proteins / genetics
  • Saccharomyces cerevisiae Proteins / metabolism*


  • Acyl Coenzyme A
  • Oxalates
  • Saccharomyces cerevisiae Proteins
  • oxalyl-coenzyme A
  • Carbon Dioxide
  • Coenzyme A Ligases
  • oxalyl-CoA synthetase, S cerevisiae