Two distinct serotonin receptors co-mediate non-photic signals to the circadian clock

J Pharmacol Sci. 2013;123(4):402-6. doi: 10.1254/jphs.13170sc. Epub 2013 Nov 29.

Abstract

Several lines of evidence indicate that serotonin type 7 (5-HT7) receptors play a critical role for non-photic resetting of the mammalian circadian clock; however, the contributions of other types of 5-HT receptors to non-photic entrainment are not yet clarified. The present study demonstrates that MKC-242, a selective 5-HT1A receptor agonist, can evoke a non-photic-like phase-response in hamsters in vivo. This phase-shifting response to MKC-242 was antagonized not only by the selective 5-HT1A receptor blocker WAY100635 but also by the selective 5-HT7 receptor blocker DR4004. These suggest that synchronous activation of 5-HT1A and 5-HT7 receptors mediates non-photic signals to the hamster circadian clock.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Circadian Clocks / genetics*
  • Circadian Clocks / physiology*
  • Cricetinae
  • Darkness*
  • Dioxanes / antagonists & inhibitors
  • Dioxanes / pharmacology
  • Dioxoles / antagonists & inhibitors
  • Dioxoles / pharmacology
  • Indoles / pharmacology
  • Male
  • Piperazines / pharmacology
  • Pyridines / pharmacology
  • Receptor, Serotonin, 5-HT1A / metabolism
  • Receptor, Serotonin, 5-HT1A / physiology*
  • Receptors, Serotonin / metabolism
  • Receptors, Serotonin / physiology*
  • Serotonin 5-HT1 Receptor Agonists / pharmacology
  • Serotonin 5-HT1 Receptor Antagonists / pharmacology

Substances

  • DR-4004
  • Dioxanes
  • Dioxoles
  • Indoles
  • Piperazines
  • Pyridines
  • Receptors, Serotonin
  • Serotonin 5-HT1 Receptor Agonists
  • Serotonin 5-HT1 Receptor Antagonists
  • serotonin 7 receptor
  • Receptor, Serotonin, 5-HT1A
  • N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide
  • osemozotan