Abstract
Several lines of evidence indicate that serotonin type 7 (5-HT7) receptors play a critical role for non-photic resetting of the mammalian circadian clock; however, the contributions of other types of 5-HT receptors to non-photic entrainment are not yet clarified. The present study demonstrates that MKC-242, a selective 5-HT1A receptor agonist, can evoke a non-photic-like phase-response in hamsters in vivo. This phase-shifting response to MKC-242 was antagonized not only by the selective 5-HT1A receptor blocker WAY100635 but also by the selective 5-HT7 receptor blocker DR4004. These suggest that synchronous activation of 5-HT1A and 5-HT7 receptors mediates non-photic signals to the hamster circadian clock.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Circadian Clocks / genetics*
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Circadian Clocks / physiology*
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Cricetinae
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Darkness*
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Dioxanes / antagonists & inhibitors
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Dioxanes / pharmacology
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Dioxoles / antagonists & inhibitors
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Dioxoles / pharmacology
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Indoles / pharmacology
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Male
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Piperazines / pharmacology
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Pyridines / pharmacology
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Receptor, Serotonin, 5-HT1A / metabolism
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Receptor, Serotonin, 5-HT1A / physiology*
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Receptors, Serotonin / metabolism
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Receptors, Serotonin / physiology*
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Serotonin 5-HT1 Receptor Agonists / pharmacology
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Serotonin 5-HT1 Receptor Antagonists / pharmacology
Substances
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DR-4004
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Dioxanes
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Dioxoles
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Indoles
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Piperazines
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Pyridines
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Receptors, Serotonin
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Serotonin 5-HT1 Receptor Agonists
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Serotonin 5-HT1 Receptor Antagonists
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serotonin 7 receptor
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Receptor, Serotonin, 5-HT1A
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N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide
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osemozotan