A 72-year-old man with a fever and abdominal pain was referred to our hospital. On admission, the patient exhibited the clinical signs of septic shock. Computed tomography revealed a rim-and septal-enhanced lesion in the left lobe of the liver with hemorrhage along the hepatic capsule. Because Klebsiella pneumoniae was detected in both the blood and aspirated abdominal fluid, the patient was diagnosed with a ruptured pyogenic liver abscess. He was successfully treated with percutaneous abscess drainage and the systemic administration of antibiotics. Non-surgical treatment for a ruptured pyogenic liver abscess is therefore effective in at least some cases.