Mechanisms underlying effects of 1,25-Dihydroxyvitamin D3 on the Th17 cells

Eur J Microbiol Immunol (Bp). 2013 Dec;3(4):237-40. doi: 10.1556/EuJMI.3.2013.4.1. Epub 2013 Nov 21.


Th17 cells, a class of CD4(+) T cells, have been identified as novel effector cells, which play a pivotal role in several inflammatory and autoimmune diseases. 1,25-Dihydroxyvitamin D3 (1,25(OH)2D3), the active form of vitamin D, has emerged as a direct regulator of immune system function in humans. Accumulating reports demonstrated that 1,25(OH)2D3 possessed anti-inflammatory activity on Th17 cells to maintain immunologic homeostasis. This report will review the novel immune regulatory role of 1,25(OH)2D3 in its potential use for Th17 cell-related inflammatory and autoimmune conditions.

Keywords: 1,25(OH)2D3; Th17; VDR; immune response.

Publication types

  • Review