Signaling at the Golgi during mitosis

Methods Cell Biol. 2013;118:383-400. doi: 10.1016/B978-0-12-417164-0.00023-9.

Abstract

The Golgi complex of mammalian cells is composed of interconnected stacks of flattened cisternae that form a continuous membrane system in the pericentriolar region of the cell. At the onset of mitosis, this so-called Golgi ribbon is converted into small tubular-vesicular clusters in a tightly regulated fragmentation process, which leads to a temporary loss of the physical Golgi-centrosome proximity. Mitotic Golgi breakdown is required for Golgi partitioning into the two daughter cells, cell cycle progression and may contribute to the dispersal of Golgi-associated signaling molecules. Here, we review our current understanding of the mechanisms that control mitotic Golgi reorganization, its biological significance, and assays that are used to study this process.

Keywords: Cell cycle progression; Fragmentation; Kinases; Mitotic entry; Reorganization.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cells, Cultured
  • Golgi Apparatus / physiology*
  • Humans
  • Intracellular Membranes / metabolism
  • Mitosis*
  • Signal Transduction*