A near-infrared fluorescence dye for sensitive detection of hydrogen sulfide in serum

Bioorg Med Chem Lett. 2014 Jan 1;24(1):314-6. doi: 10.1016/j.bmcl.2013.11.016. Epub 2013 Nov 19.

Abstract

Cy-Cl, a cationic near-infrared cyanine dye, readily reacts with hydrogen sulfide (H2S) via nucleophilic thiolation to give dose-dependent 'turn-off' fluorescence and colorimetric read-out, allowing selective detection of low levels of H2S in serum and imaging of mitochondrial H2S in living cells.

Keywords: Bioimaging; Cyanine dye; Hydrogen sulfide; Mitochondria; Near-infrared; Serum.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Fluorescent Dyes / chemistry*
  • HeLa Cells
  • Humans
  • Hydrogen Sulfide / blood*
  • Mitochondria / chemistry
  • Spectrometry, Fluorescence
  • Spectrophotometry, Ultraviolet

Substances

  • Fluorescent Dyes
  • Hydrogen Sulfide