Biomarkers in acute respiratory distress syndrome

Curr Opin Crit Care. 2014 Feb;20(1):47-55. doi: 10.1097/MCC.0000000000000048.


Purpose of review: The article provides an overview of efforts to identify and validate biomarkers in acute respiratory distress syndrome (ARDS) and a discussion of the challenges confronting researchers in this area.

Recent findings: Although various putative biomarkers have been investigated in ARDS, the data have been largely disappointing and the 'troponin' of ARDS remains elusive. Establishing a relationship between measurable biological processes and clinical outcomes is vital to advancing clinical trials in ARDS and expanding our arsenal of treatments for this complex syndrome.

Summary: This article summarizes the current status of ARDS biomarker research and provides a framework for future investigation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biomarkers / blood
  • Female
  • Humans
  • Intercellular Adhesion Molecule-1 / blood
  • Interleukin-6 / blood
  • Interleukin-8 / blood
  • Male
  • Mucin-1 / blood
  • Plasminogen Activator Inhibitor 1 / blood
  • Receptor for Advanced Glycation End Products / blood
  • Research
  • Respiration, Artificial / adverse effects*
  • Respiratory Distress Syndrome / blood
  • Respiratory Distress Syndrome / therapy*
  • Tumor Necrosis Factor-alpha / blood
  • Vascular Endothelial Growth Factor A / blood
  • Ventilator-Induced Lung Injury / blood
  • Ventilator-Induced Lung Injury / therapy*
  • Vesicular Transport Proteins / blood
  • von Willebrand Factor / metabolism


  • Biomarkers
  • Interleukin-6
  • Interleukin-8
  • MUC1 protein, human
  • Mucin-1
  • Plasminogen Activator Inhibitor 1
  • Receptor for Advanced Glycation End Products
  • SERPINE1 protein, human
  • Tumor Necrosis Factor-alpha
  • VEGFA protein, human
  • VPS51 protein, human
  • Vascular Endothelial Growth Factor A
  • Vesicular Transport Proteins
  • von Willebrand Factor
  • Intercellular Adhesion Molecule-1