[Vitamin B9]

Rev Prat. 2013 Oct;63(8):1079, 1081-4.
[Article in French]


Vitamin B9 is represented by the group of folate, whose structure is derived from folic acid. The biologically active form is reduced tetrahydrofolates, serving as an essential cofactor in methylation reactions, including the vitamin B12-dependent formation of methionine from homocysteine, and as a carrier of one-carbon units involved in the synthesis of purines and pyrimidines. Folate deficiency is associated with hyperhomocysteinemia, megaloblastic anemia, leuco- and thrombocytopenia, cardiovascular disease, embryonic defects, in particular neural tube defects, and, possibly, malignancies, depression and cognitive impairment.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Female
  • Folic Acid / physiology*
  • Folic Acid Deficiency* / diagnosis
  • Folic Acid Deficiency* / etiology
  • Folic Acid Deficiency* / therapy
  • Humans
  • Pregnancy
  • Risk Factors


  • Folic Acid