Virus Variation Resource--recent updates and future directions

Nucleic Acids Res. 2014 Jan;42(Database issue):D660-5. doi: 10.1093/nar/gkt1268. Epub 2013 Dec 4.


Virus Variation ( is a comprehensive, web-based resource designed to support the retrieval and display of large virus sequence datasets. The resource includes a value added database, a specialized search interface and a suite of sequence data displays. Virus-specific sequence annotation and database loading pipelines produce consistent protein and gene annotation and capture sequence descriptors from sequence records then map these metadata to a controlled vocabulary. The database supports a metadata driven, web-based search interface where sequences can be selected using a variety of biological and clinical criteria. Retrieved sequences can then be downloaded in a variety of formats or analyzed using a suite of tools and displays. Over the past 2 years, the pre-existing influenza and Dengue virus resources have been combined into a single construct and West Nile virus added to the resultant resource. A number of improvements were incorporated into the sequence annotation and database loading pipelines, and the virus-specific search interfaces were updated to support more advanced functions. Several new features have also been added to the sequence download options, and a new multiple sequence alignment viewer has been incorporated into the resource tool set. Together these enhancements should support enhanced usability and the inclusion of new viruses in the future.

Publication types

  • Research Support, N.I.H., Intramural

MeSH terms

  • Databases, Genetic*
  • Genes, Viral
  • Genome, Viral
  • Genomics
  • Internet
  • Molecular Sequence Annotation
  • Orthomyxoviridae / genetics
  • Sequence Alignment
  • Viral Proteins
  • Viruses / genetics*


  • Viral Proteins